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Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients with Stage II or III Breast Cancer

Principal Investigator: Justin Bekelman, MD 

The Radiotherapy Comparative Effectiveness (RADCOMP) Consortium will conduct a pragmatic randomized clinical trial in which 1,716 patients with stage II and III breast cancer involving lymph nodes under the arm or above the collarbone will be randomized after surgery to either proton therapy or photon therapy, the current standard treatment. Patients will be followed to determine differences in heart problems, cancer control, and health-related quality of life (HRQOL) after treatment.

Funder: PCORI