Doctor Karlawish’s research focuses on ethical issues in human subjects research and the care of persons with late-life cognitive disorders such as Alzheimers Disease and Parkinsons Disease. His research investigates issues in dementia drug development, informed consent, quality of life, research and treatment decision making, and voting by persons with cognitive impairment and residents of long term care facilities. He has studied elderly persons’ willingness to allow family to serve as a proxy for research decision making, consent capacity, whether Alzheimers Disease clinical trials can be redesigned to increase family caregivers’ willingness to enroll, and voting rights for older adults with cognitive impairment.
Sperling R, Karlawish JH, Johnson KA. Preclinical Alzheimer's diesease-the challenges ahead. Nat Rev Neurol. 2013;9(1):54-8.
Shulman MB, Harkins KA, Green RC, Karlawish J. Using AD biomarker research results for clinical care: A survey of ADNI investigators. Neurology. 2013;81(13):1114-21.
Grill JD, Karlawish J, Elashoff D, Vickrey BG. Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment. Alzheimers Dement. 2013;9(3):355-9.
Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies WH. Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Taks Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association. J Nucl Med. 2013;54(3):476-90.
Johnson K, Minoshima S, Bohnen N, Donohoe K, Foster N, Herscovitch P, Karlawish J, R$owe C, Hedrick S, Pappas V, Carrillo M, Hartley D. Update on appropriate use criteria for amyloid PET imaging: Dementia experts, mild cognitive impairment, and education. J Nucl Med. 2013;54(7):1011-3.
Arias JJ, Karlawish J. Confidentiality in preclinical Alzheimer's studies: when research and medical records meet. Neurology. 2014;82(8):725-9.
Karlawish J, Green RC. Minding the aging brain: Are we ready for personalized medicine? Am J Psychiatry. 2014;171(2):137-9.
Sperling RA, Rentz DM, Johnson KA, Karlawish J, Donohue M, Salmon DP, Aisen P. The A4 study: Stopping AD before sympotms begin? Sci Transl Med. 2014;6:228fs13.
Karlawish J. How are we going to live with Alzheimer's disease? Health Aff (Millwood). 2014;33(4):541-6.